From June 2022, a zinc oxide ban, prohibiting the use of therapeutic doses of zinc oxide (ZnO) in animal feeds to control post-weaning diarrhea in piglets will come into effect in the European Union (EU). Although ZnO can still be used as a feed additive after this date, it will only be allowed at the maximum permitted dose rate of 150 ppm total dietary zinc. Before we discuss why all EU pig producers need to be ready to rear their pigs without pharmacological levels of ZnO by 2022, it is important to understand why the use of high levels of ZnO in swine nutritional diets has increased dramatically across the globe in recent years.

Where it all began

At weaning, piglets are subject to a multitude of stress factors over a very short period that contribute to gastrointestinal tract and immune system disturbances. These factors can be:

1. Nutritional: Abrupt dietary change from sow milk to a dry, pelleted, predominantly vegetable-based diet formulation.

2. Environmental: Moving to new nursery accommodation with different housing conditions.

3. Health-based: Loss of passive immunity from the sow.

4. Physiological: Abrupt maternal separation, being handled and transported and mixing with unfamiliar pigs from other litters.

Because the pigs are under such stress, the early post-weaning period is typically characterized by poor growth performance (e.g., reduced feed intake) and increased susceptibility to post-weaning diarrhea.

Traditionally, pig producers relied heavily on antibiotic growth promoters in pre-starter and starter feeds to control pathogenic infections (mainly caused by enterotoxigenic E. coli) and improve pig growth performance in the first few weeks after weaning. This was common practice until various governmental bodies banned the use of antibiotics as growth promoters, such as the European Parliament in 2003, due to growing concerns over increasing levels of antimicrobial resistance (AMR). The continual spread of AMR has dangerous consequences for not only animal but also human health.

Following this ban, pig producers had to seek alternatives to maintain optimal gut health and to reduce this post-weaning performance drop. As a result, the use of high levels of ZnO in piglet feeds (2,000 ppm or higher) became more widespread and was seen as common practice in the swine industry. It was shown to be an effective and relatively inexpensive tool for preventing and controlling post-weaning diarrhea, with subsequent improvements in piglet growth performance, feed intake and digestion. Although the precise mode of action of ZnO against post-weaning diarrhea in weaned piglets is not yet fully understood, it is believed to be related to a significant improvement in both intestinal morphology (i.e., improved structure and function) and nutrient digestion and absorption.

Why ban pharmacological levels of ZnO?

Though there are several benefits of using ZnO in piglet feeds (preventing post-weaning diarrhea, maintaining health and performance, etc.), recent reports have highlighted its environmental impact, and we became aware of its contribution to the spread of AMR. It is, therefore, not surprising that regulations around its use are changing and why the EU decided to ban the use of pharmacological levels of ZnO in June 2022. However, it is not all bad news for the European pig industry, as there are several potential benefits to the upcoming ban on ZnO. Some of these benefits are:

1. Reduced environmental pollution

As previously mentioned, there are environmental concerns over the continued use of high levels of ZnO. This is primarily because zinc accumulates in soil after zinc-rich pig manure is applied to the land as an organic fertilizer. These high levels of zinc in the soil and surface water are deemed an environmental pollutant and health risk and may also impact the absorption of other trace elements, such as iron.

2. Preventing antimicrobial resistance

Recent studies and reports have demonstrated ZnO's contribution to the increase of AMR, as high levels of ZnO may increase the proportion of multi-drug-resistant E. coli in the intestines of piglets.

3. Avoiding zinc toxicity

Zinc remains a heavy metal and is, therefore, toxic to many living organisms, including pigs. Studies show that prolonged use of pharmacological levels of ZnO may negatively affect piglet health and performance, as demonstrated by a marked decrease in feed intake.

4. Preventing nutritional interactions

High levels of ZnO can have a negative effect on phytase activity (an enzyme that is included in piglet feeds to enhance digestion), whereby the phosphorous cannot be released from phytase due to the formation of a complex of zinc with P-phytate. When ZnO is removed from piglet feeds, it should have a positive effect on phytase efficiency.

5. Avoiding changes to gut microbial composition

The use of pharmacological doses of ZnO may also cause changes to the gut microbial composition of piglets during the early post-weaning period by suppressing the growth of beneficial bacteria, such as Lactobacilli. Such changes may negatively affect intestinal development and health in young piglets.

What is in store for pig-producing countries outside the EU?

Canada: Until recently, ZnO was typically included in piglet feeds at 2,500–5,000 ppm in Canada. However, Canada is now in the midst of imposing similar restrictions to that of the EU, which will see the level of ZnO allowed in piglet feeds reduced down to nutritional levels of 350 ppm.

China: The use of high levels of ZnO also came under scrutiny in China, and, as a result, China has drastically reduced its level of authorized dietary zinc supplementation, going from 2,250 ppm to 1,600 ppm in 2018.

United States and some Asian countries: It is very likely that the United States and some Asian countries will also implement similar restrictions on the use of pharmacological levels of ZnO in piglet diets in the near future. Although there are no restrictions currently in place in these regions, it is vital that swine producers avoid over use and start the process of working towards ZnO alternatives so that they are prepared when a ban inevitably comes into effect.

Until recently, ZnO represented one of the vital nutritional strategies for preventing and controlling diarrhea in young piglets and the associated detrimental post-weaning 'growth check.' However, increasing concerns over environmental pollution and contributions to the spread of AMR have led to an EU ban on the use of high levels of ZnO in piglet diets. Adopting a holistic strategy that encompasses optimal nutrition, management, biosecurity, health and welfare practices will be key to ensuring that pigs can thrive and survive in a post-ZnO era.

Learn how the Alltech Seed, Feed, Weed solution can help you remove ZnO from your piglet diets, and start the conversation about how you can begin transitioning to ZnO-free piglet production by contacting the Alltech Gut Health Management team today.

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Successful pig production without zinc oxide: How to thrive and survive